枳实的化学成分研究.pdf

中国科技论文在线 枳实的化学成分研究# 陈刚，张鸥，王海峰，裴月湖** （沈阳药科大学中药学院，沈阳 110016 ） 5 摘要：目的：研究芸香科柑橘属植物枳实干燥幼果的乙醇提取物的乙酸乙酯部分，对其中的 化学成分进行分离鉴定。方法：利用硅胶柱色谱，凝胶柱色谱（Sephadex LH-20 ），制备高 效液相色谱等手段进行分离纯化，根据理化性质和光谱数据对化合物进行了结构鉴定。结果 从枳实的乙酸乙酯萃取部分分离得到 5 个化合物，分别鉴定为:N-Benzoyl tyramine methyl ether(1), 桔皮晶(2), 5-降甲基蜜桔黄素(3), isomeranzine(4), 蜜桔黄素(5)。化合物1 为首次从 10 该属植物中分离得到。 关键词：天然药物化学；化学成分；枳实 中图分类号：R284 Chemical constituents from Fructus Aurantii Immaturus 15 CHEN Gang, ZHANG Ou, WANG Haifeng, PEI Yuehu (School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016) Abstract: Aim of this study: To study on the chemical constituents of the ethyl acetate extraction of Fructus Aurantii Immaturus, including isolation and structure determination. Materials and 20 methods: Sephadex LH-20, silica gel and prepative liquid chromtagrahpy were used to isolate the chemical constituents of the ethyl acetate extraction systematically and the isolates were determined based on their physical and chemical properities as well as spectral data. Results: Five compounds were isolated and determined as N-Benzoyl tyramine methyl ether(1), tangeretin(2), 5-normethylnobiletin(3), isomeranzine(4), nobiletin(5). Compounds 1 were isolated from this 25 genus for the first time. Key words: natural product chemistry; chemical constituents; Fructus Aurantii Immaturus 0 引言 枳实(Fructus Aurantii Immaturus ）是芸香科植物酸橙(Citrus aurantium L ．)及其栽培变种 30 或甜橙(Citrus sinesis Osbeck) 的干燥幼果，具有破气消积、化痰散痞的作用，用于治疗积滞 [1] 内停、痞满胀痛、泻痢后重、大便不通