氧化应激在良性前列腺增生和前列腺癌发病中的作用研究_张志涛.pdf

网络出版时间：2012-10-25 09:29 代预防医学Modern Preventive Medicine DOI: 网络出版地址 /kcms/detail/51.1365.R0929.004.html 化应激在良性前列腺增生和 前列腺癌发病中的作用研究 张志涛1 张红艳2 邯郸市中心医院泌尿外二科袁河北省邯郸市袁056002 曰2 河北工程大学医学院袁河北省邯郸市袁056002 冤 摘要: 目的 明确氧化应激在良性前列腺增生和前列腺癌发病中的作用遥 方法 检测氧化应激指标一氧化氮 NO冤尧 丙二醛 MDA 冤尧还原型谷胱甘肽 GSH冤在正常小鼠尧小鼠良性前列腺增生和前列腺癌细胞中的表达袁统计学分析比较其差异遥 结果 NO尧 MDA尧GSH 水平在三组之间均有显著差异(P约0.00 1)遥即前列腺癌组的NO尧MDA 水平高于前列腺增生组袁前列腺增生组的NO尧MDA 水 平高于对照组曰前列腺癌组的GSH 水平低于前列腺增生组袁前列腺增生组的GSH 水平低于对照组遥 结论氧化应激与前列腺增生与 前列腺癌的发生有关袁氧化应激指标在小鼠良性前列腺增生和前列腺癌细胞中的表达存在差异袁前列腺癌细胞中的氧化应激反应强 于良性前列腺增生遥 关键词 氧化应激曰良性前列腺增生曰前列腺癌曰NO 曰MDA 曰GSH 中图分类号 R446.19 文献标识码 A 文章编号:20 1202358 Study on Effect of Oxidative Stress on Benign Prostatic Hyperplasia and Prostatic Carcinoma ZHANG Zhi-tao,ZHANG Hong- yan. The Second Urop oies is Surgical Dep artment in H an Dan Central Hosp ital, Medical College of He iBe i Engineering Univers ity, Handan 056002, China Abstract: OBJECTIVE To identify the effect of oxidative stress on benign prostatic hyperplasia and prostatic carcinoma. METHODS To compare the level of oxidative stress index ,such as NO 袁MDA,GSH,in normal mice ,mice with benign prostatic hyperplasia and mice with prostatic carcinoma. Then statistic analysis was done. RESULTS There were significant deviation in the level of NO尧MDA and GSH among 3groups (P约0.001). The level of NO and MDA in PC group were higher than those in BPH group. The level of NO and MDA in BPH group were higher than those in control group. The level of GSH in PC group were lower than