IL_4和IFN_在反流性食管炎_省略_的表达及其与病理和内镜分级的关系_钟英强.pdf

()2009 5 3 5　ChinJClinicians(ElectronicEdition), May15, 2009, Vo.l3, No.5 ·72 3 · · · IL-4 IFN-γ Barrett 钟英强　许哲　沈溪明　李海刚　刘娟　李山山　曾志勇 　　【】　　 IL-4 IFN-γ (refluxesophagiti,sRE) Barrett (barrettsesophagu,sBE) 。　RE、BE 30 。 RE RE BE。 IL-4 IFN-γ SABC 。　IFN-γ RE (5.39 ±1.14 ) BE (5.94 ±1.79 ) (0.7 1 ±0.24 )(P0.00 1 );IL-4 BE (4.45 ± 1.41) RE (1.28 ±0.35 ) (0.80 ± 0.20 )(P0.00 1);BE RE;RE IFN-γ (r=0.509, P0.0 1 )、 (r=0.493, P0.0 1 )。 　Th1/Th2 RE BE, RE Th1, BE Th1、Th2。 【】　, ;　Barrett;　;　;　 ;　 4;　Ⅱ ExpressionofIL-4 andIFN-γofthebiopsyesophagealmucosaofpatientswith refluxesophagitisandBarrettesophagusandtheirrelationshipwithpathological andendoscopegrading　ZHONGYing-qiang, XUZh,eSHENXi-ming, LIHai-gang, LIUJuan, LIShan-shan, ZENGZhi-yong.DeparmtentofGastroenterolog,ytheSecond AffiliatedHospita,lSunYat-senUniversit,yGuangzhou510120, China Correspondingautho:rZHONGYing-qiang, Emai:lzhongyingqiang@21 : (JRC01) :5 10 120　, (、、、、), (、); () :, Emai:lzhongyingqiang@2 1 ·7 24 · ()2009 5 3 5　ChinJClinicians(ElectronicEdition), May15, 2009, Vo.l3, No.5 【Abstract】　Objective　ToinvestigateexpressionofIL-4 andIFN-γofthe biopsyesophagealmucosaofpatientswithrefluxesophagitis(RE)andBarrett esophagus(BE)andtheirrelationshipwithpathologicalandendoscopegrading. Methods　ThirtycasesinRE, BEandthecontrolgrouprespectivelywereenrolledthe tes.tTorecordtheendoscopicandpathologicalfeaturesofpatientswithRE, and pathologicalfeaturesofpatientswithBE.TheexpressionofIL-4 andIFN-γofall specmienswere detected by SABC of mimuno-histochemistry (IHC). Results　ExpressionofIFN-γwashigherinBE(5.94 ±1.79 )orinRE(5.39 ± 1.14 )thaninthecontrolgroup(0.7 1 ±0.24 )(P0.0 1 ), andexpressionofIL-4 washigherinBEgroup(4.45 ±1.4 1)thanintheREgroup(1.28 ±0.35 )orinthe control(0.80 ±0.20 )(P0.01 ).Therewasmoreseriouspathologicaldamagein theREthanintheBEgroup.The