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K_ras基因点突变在非小细胞肺癌中的意义
264 ( ) Vol.26 o. 4
2 0 0 5 8 Journal of Xi an Jiaotong University(Medical Sciences) Aug. 2005
Kras 基因点突变在非小细胞肺癌中的意义
1 2 3 2
张健杰 , 杨德昌 , 吉昌华 ,何积银
( 1. , 518001;2. , 710004;
3., 710033)
:目的 Kras 方法
41 ( SCLC) , 21 21Kras
12 结果 41 SCLC 10 Kras ,24. 39% Kras
, Kras ,
,Kras ,
21 4 Kras , Kras
,( P 0. 05) 结论 Kras 12 SCLC
,Kras
:; ; Kras
:R734.2 : A : 2005
Correlation between Kras gene mutation and nonsmall cell lung cancer
1 2 3 2
Zhang Jianjie , Yang Dechang , Ji Changhua , He Jiyin
( 1. Department of Internal Medicine, Railway Hospital, Shenzhen 518001; 2. Department of
Respiration, Second Hospital of Xian Jiaotong University, Xian 710004; 3. Department
of Biochemistry, T he Fourth Military Medical University, Xian 710033, China)
ABSTRACT: Obj ective To explore the clinical significance of Kras mutation in nonsmall cell lung cancer.
Methods A Kras codon 12 point mutation was detected by restriction fragment length polymorphisms combined
with polymerase chain reaction in 41 tissues from nonsmall cell lung cancer ( SCLC) , 21normal tissues from nearby
tumor and 21 lymph nodes from nearby bronchi. Results Kras mutation was detected in 10 of 41 SCLC
(24.39%) . There was no relationship between Kras mutation and the age, sex, differentiation of tumor, tumor
volume, histologic type and tumor stage. Kras mutation was more common in smoking group than in nonsmoking
group, but the statistical comparison was not significant. There was a strong link between cigarette smoking and Kras
point mutation in lung adenocarcinoma, but there was
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