疏水过滤器完整性测试.pdf

Hydrophobic Integrity Testing 疏水性过滤器完整性测试 过滤/完整性测试培训课程 What you will learn 主要内容 • The types of particles and microorganisms used for testing hydrophobic filters 测试疏水性滤膜所用的颗粒及微生物的种类 • How we can test hydrophobic filters with the same liquid properties we used to test hydrophilic filters 如何利用测试亲水性滤膜的液体来测试疏水性滤膜 • What new tests are available to address the limitations of alcohol based testing –HydroCorr 新的测试方法可以去除使用酒精Hydrocorr • How and when to use HydroCorr to it’s maximum advantage 如何及合适使用Hydrocorr方法更能体现其优点 Particle Based Integrity Testing 测试所用的颗粒 • Microorganism - Destructive Test • 微生物测试破坏性测试 – Aerosol microorganisms or liquid bacterial challenge – 气雾型微生物或者使用液状细菌进行挑战 – Phage (T1, T3, phiX)噬菌体 – Bacteria (B. diminuta) 细菌(缺陷型假单孢杆菌) • Aerosol Based - Non-destructive Test • 气雾测试非破坏性测试 – Smoke (D.O.P., Glycerol, Corn oil, etc) 烟雾 – Methylene Blue, Sodium Flame 亚甲基蓝,钠火焰 – Issues注意点 Particle Distribution must be uniform颗粒分布必须是均一的 Must have correlation of particles vs microorganisms 颗粒与微生物之间需要有相关性 High equipment cost设备成本高 Difficult to perform in-situ很难在线测试 Traditional Testing Principles 传统测试原理 • Typical wetting liquids are compressed air Isopropyl Alcohol (I.P.A.), Methanol, Tert-butyl Alcohol, or a mixture of one of these and water • 典型的润湿液是异丙醇,甲 醇或他们与水的混合物 • Uses same principles as a hydrophilic test • 使用与亲水性滤膜测试相同 的原理 Alcohol / Water Gas Flow Curve 酒精/水气体流速曲线 – Dont use 100% solvent, check gauges, set pressure accurately, check for correct test gas, look for distinctive change in gas flowrate – 不要使用100%的溶剂.核实压力表