应用简易葡萄糖处置指数评估多囊卵巢综合征患者胰岛_细胞功能.pdf

2007 1 2 Chin J Diabetes, February 2007, Vol 1 , No 2 67 冯静 程庆丰 丘彦 白晓苏 刘秀蓉 李启富 ! OGTT ( DI= I / G ∀ 1/ H OM A 30 30 IR) ( PCOS) 79 PCOS OGT T ( NGT ) ( 47 ) ( IGT ) ( 32 ) , Botnia , , DI= ∀ ( 1) I / G ∀ 1/ HOMAIR DI ( NGT r 0 1, 30 30 P # 0. 001; IGT r 0. 3, P 0.0 ) ( 2) I / G ∀ 1/ HOMAIR OGTT 30 30 (P 00 ) , 2hPG ( P 0. 0001) I / G ∀ 1/ H OMAIR Botnia DI , 30 30 , ! ; ; Evaluating isletcell function by simple glucose disposition index obtainedfrom OGTT F EN G Jing , CH E N G Qingf eng , QI U Yan, et al . Dep artment of End ocrinology , T e F irst Af f iliated H osp ital of C ongqing Medical Univers ity , C ongqing 400016, C ina Corresp onding aut or : L I Qif u, Email : liqif u@yea . net Abstract! Objective To explore whether simple glucose disposition index ( I / G ∀ 30 30 1/ HOMAIR) obtained from OGTT is reliable for evaluating islet cell f unction in PCOS patients. Methods 79 subjects w ere given oral glucose t olerance tests ( OGT T) and Botnia glucose clamp w hich was an intravenous glucose tolerance test ( IVGTT) w as follow ed by an euglycemichyperinsulinemic clamp. The subjects were divided into NGT and IGT group(47 vs 32 subjects) . Glucose disposition in dex ( DI) was calculated as the product of IS and F ( DI= IS ∀ F) . Results ( 1) I / G ∀ 1/ 30 30 HOMAIR show ed positive linear correlat ion w ith DI (AIR ∀ ClampIS) obtained f rom Bot nia glucose clamp( NGT , r= 0. 1, P # 0. 001; IGT , r= 0. 3, P 0.0 ) . (2) I30/ G30 ∀ 1/ HOMAIR show ed inverse linear