桑通颗粒的主要药效学研究_吕献青.pdf

# 1378# 辽宁中医杂志 2010年第 37 卷第 7期 1 1 1 1 2 , , , , ( 1. 石家庄市中医院, 河北石家庄 050051; 2. 河北医科大学中医学院, 河北石家庄 050091) : 目的:观察桑通颗粒的止咳祛痰平喘作用方法: 将实验动物随机分为 5组, 即空白 照组, 桑通颗粒高 中低剂量组和阳性 照组; 采用氨水引咳法观察桑通颗粒 致咳小鼠模型的影响; 采用酚红排泌试验观察桑通颗粒的 祛痰作用; 采用磷酸组胺- 乙酰胆碱引喘法观察桑通颗粒 致喘豚鼠模型的影响结果: 与空白 照组比较, 桑通颗粒 各治疗组致咳潜伏期和引喘潜伏期明显延长, 咳嗽次数明显减少, 酚红排泌量明显增加(P 01 05 或P 0101); 桑通颗 粒各组与阳性 照组比较, 差别无统计学意义(P 0105)结论:桑通颗粒具有较好的止咳祛痰平喘的作用 : 桑通颗粒;止咳; 祛痰; 平喘; 动物实验 : R28515 : A : 1000- 1719( 2010) 07- 1378- 02 The Experimental Study on M ain Pharmacodynam ics of Sangtong Granule 1 1 1 1 2 LVX ian-qing , JIAO L i-hong , WANG Zhi-cheng , L I Rui, LI Chen ( 1. Sh ij iazhuang raditional ChineseM ed icalH osp ital, Shij iazhuang 050051, H ebei, China; 2. H ebeiM ed ical University College of raditional ChineseM ed icine, Shij iazhuang 050091, H ebei, China) Abstract: Objective: To observe the antit ss ive, expectorant and antiasthm atic actions of Sangtong gran le. M ethods: The ex- permi ental an mi alsw ere random ized into 5 gro ps: control gro p, high- , moderate- and low - dose Sangtong gran le gro ps, positive control gro p. the effect of Sangtong Gran le on co gh m icew ere observed by the method of strong aq a ca sing co gh; the f ction of elmi inating phlegm w ere observed by phenol red excrete; the effect of Sangtong Gran le on bronchial asthm a cavia cobaya w ere observed by them ethod of histam ine phosphate ca s ing asthm a.R esults: Com paredw ith control gro p, the stage of la- tency of co gh and asthm a w ere extend, the freq ency of co gh w ere decreased, and the q an tity of phenol red excrete w er