ARTICLE IN PRESS In vivo neuropathology of the hippocampal formation in AD A radial mapping.pdfVIP

DTD 5 ARTICLE IN PRESS YNIMG-03830; No. of pages: 7; 4C: 3, 4, 5 /locate/ynimg NeuroImage xx (2006) xxx – xxx In vivo neuropathology of the hippocampal formation in AD: A radial mapping MR-based study G.B. Frisoni,a,b,d,* F. Sabattoli, a A.D. Lee, c R.A. Dutton,c A.W. Toga, c and P.M. Thompsonc aLENITEM Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS Centro S. Giovanni di Dio-FBF, Brescia, Italy bPsychogeriatrics Unit, IRCCS Centro S. Giovanni di Dio-FBF, Brescia, Italy cLaboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA dAFaR Associazione Fatebenefratelli per la Ricerca, Rome, Italy Received 17 September 2005; revised 2 March 2006; accepted 7 March 2006 Early involvement of the hippocampal formation is the biological basis subcortical structures. The main input to the hippocampal of the typical learning deficit in Alzheimer’s disease (AD). However, the formation comes from the entorhinal cortex, and the major output hippocampal formation is unevenly affected by AD pathology, deposits arises from the subicular region. In AD, the entorhinal cortex, the of plaques and tangles being particularly dense in the CA1 field and CA1 field, and the subicular region are all heavily affected by cell subiculum. The aim