Bupropion hydrochloride_31677-93-7_DataSheet_MedChemExpress.pdfVIP

Product Data Sheet Product Name: Bupropion hydrochloride CAS No.: 31677-93-7 CCatt. NNo.: HYHY-B0403AB0403A MWt: 276.20 Formula: C13H19Cl2NO Purity : 98% Solubility: DMSODMSO Mechanisms: Pathways:Others; Target:Others Biological Activity: Bupropion Hydrochloride is a unicyclic, aminoketone antidepressant. Target: Dopamine Reuptake; Norepinephrine Reuptake Bupropion is a second-generation antidepressant, with a mechanism of action different from most antidepressants, in that it is a dopamine and norepinephrine reuptake inhibitor [1]. Bupropion is approved for use in major depression and seasonal affective disorder and has demonstrated comparable efficacy to other antidepressants in clinical trials. Bupropion is also useful in augmenting a partial response to selective serotonin reuptake inhibitor antidepressants, although bupropion should not be combined with monoamine oxidase inhibitors [2]. Bupropion has demonstrated efficacy comparable to that of other antidepressants [3]. ... References: [1]. Moreira, R., The efficacy and tolerability of bupropion in the treatment of major depressive disorder. Clin Drug Investig, 2011. 31 Suppl 1: p. 5-17. [2]. Foley, K.F., K.P. DeSanty, and R.E. Kast, Bupropion: pharmacology and therapeutic applicationsapplications. ExpertExpert RevRev NeurotherNeurother, 66((99):): pp.6565. [3]. Stahl, S.M., et al., A Review of the Neuropharmacology of Bupropion, a Dual Norepinephrine and Dopamine Reuptake Inhibitor. Prim Care Companion J Clin Psychiatry, 2004. 6(4): p. 159-166. Caution: Not fully tested. For research purposes only Medchemexpress LLC