Classification of primary immunodeficiency disease research progress.doc

Classification of primary immunodeficiency disease research progress [Keywords:] PID; PID classification; PID occurrence rate Primary immunodeficiency disease (primary immunodeficiency diseases, PID) is a composition by the immune system caused by genetic defects in a group of syndromes that can lead to resistance to infection, immune function and stability, ability to reduce immune surveillance, causing various diseases. From 1952 Bruton first confirmed reports of congenital absence of C for the immune deficiency disease hypergammaglobulinemia since the study of PID has experienced nearly 60 years. particularly in the last 30 years, molecular genetics and immunology in progress, leading to more and more more Renlei PID was found and identified, has so far found 160 kinds of PID [1], to deepen people’s understanding of the PID, it has become a worldwide public started to pay attention to an important public health problem, has been more and more State of the pie. In this paper, the discovery and study of history PID, PID classification rate of progress and the occurrence of various types of PID to focus on other aspects. The discovery and study of history 1PID 50 years before the 20th century, lethal infection of the more common, people know little about the immune deficiency disease. Widespread use of antibiotics after World War II, recognized the lymphocyte plays a key role in host defense and to apply protein electrophoresis antibodies in serum proteins, which can be sensitive to infection in patients with hereditary identification .1952 pediatrician Bruton in the United States reported a case of 8-year-old boy suffering from non-C hypergammaglobulinemia (agammaglobulinemia) [2], through his genetics ( occurred in boys, there is family history of X-linked recessive inheritance), the clinical course of disease (early onset, recurrent pyogenic infection, antibiotics can not cure) and Immunology (no C globulin serum electrophoresis, with pneumococcal, di