乳腺癌复发转移影响因素的病例对照研究.pdfVIP

中国实用护理杂志2015 年4 月 11 日第 31 卷第 11 期 ChinJ Prac Nurs ,April 112015 ， Vo1. 311旦旦 795 . ·科研之窗· 乳腺癌复发转移影响因素的病例对照研究 张立力 刘翠婷 [摘要] 目的 探讨乳腺癌术后复发转移的影响因素，为确定乳腺癌复发转移高危人群的筛检 与随访指标提供科学依据。方法采用病例对照研究，2004 年 1 月至2010 年口月在广州市南方医院 经病理确诊乳腺癌的生存病例，根据纳入标准分为病例组与对照组进行调查，采用非条件Logistic 回归 分析。结果 多因素分析结果显示，精神剌激[ OR=1O.926， 959毛C/(5.041-23.682) ] 、口服避孕药服用 史[ OR=2.634，959毛CI( 1.548-4.482) ]、乳房良性疾病史[ OR=5.1 83， 959毛C/(2.1 ∞-12.790) ]、人表皮生长 因子受体-2(HER2)阳性[ OR=2.257，959毛CI( 1.326-3.843) ]、腋窝淋巴结转移[ OR=2.021 ,95%CI( 1.272- 3.212) ]、远处转移[ OR=3.718，959毛C/(2.1 25-6.503) ]可能是乳腺癌术后复发转移的危险因素。而定期 运动[ OR=0.460, 959毛C/( 0.234-0.905) ]、疾病分期低[ OR=0.106，959毛CI( 0.022-0 .498) ]、母乳喂养时间 长[ OR=0.053，959毛CI(O.ω9-0.316) ]、高大豆异黄酬摄入量[ OR=0.154, 959毛CI( 0.032- 0.745) ]则降低 乳腺癌术后复发转移风险。结论对有良性乳腺疾病史的乳腺癌患者加强关注，做到及时复查、早发 现、早期诊断、早期治疗，同时提高身体与心理素质，减少口服避孕药、延长母乳喂养时间、增加豆类食 品的摄入量对预防乳腺癌术后复发转移具有重要的作用。 [关键词] 乳腺肿瘤; 复发; 危险因素; 病例对照研究 A case-control study on the risk factors of rec町rence and metastasis in breast cancer Zhang Lilt, Liu Cuiting. School 01 Nursing, Southem Medic a1 University, Guangzhou 510515, Chinα Correspondιng author: Zhang Lili, Email:zhanglili_gz @126.com [Abstract] Objective To explore the risk factors of breast cancer recurrence for the cause explo- ration and prevention of the disease. Methods Wi由 matched case-control me出od， a s旧vey was conducted among survival cases of histologically diagnosed breast cancer patients in Southem hospital from January 2004 to December 2007 in Guangzhou city. The survival cases were divided into case group and control group according to the inclusion criteria. Unconditional logistic model was used to analyze the data. Results Multiple factors logistic 陀gression analysis showed mental stimulations [OR =10.926 , 959毛 CI σ.041-23.682) ], oral co