乳腺癌远端转移与外周血血脂水平的相关性.pdfVIP

实用临床医药杂志 .66. Journal of Clinical Medicine in Practice 2015 年第 19 卷第23 期 乳腺癌远端转移与外周血血脂水平的相关性 陈晓春 (湖北省武穴市第一人民医院肿瘤科，湖北武穴， 4354∞) 摘 要:目的 探讨乳腺癌远端转移与外周血血脂水平的相关性。方法将患有乳腺癌并伴有远处转移的患者列为观察 组，将未发生远端转移的乳腺癌患者作为对照组。结果 观察组患者血脂中的 TC(t =3. 234 ,P =0. ∞2) 、 TG(t=4.111 ， P O. ∞1 )、LDL-C(t=3.361 ， P=O. ∞1) 水平显著高于对照组(P0.05); 观察组患者中 CA125 (t = 2. 147 , P = 0.035) , CA15-3 (t =2. 272 , P =0.026) 含量水平显著高于对照组(P0.05); ROC 曲线显示，当 CA15-3 截点值为54.75 U/mL时，对乳腺癌远 端转移诊断的敏感性为75% ，特异性为72.5% ，诊断价值优于CA125; 血清中 TC、 TG、山L-C 含量与肿瘤标志物 CA125 、 CAI5- 3 呈显著正相关(P0.05) 。结论血脂中TC 、 TG、山L-C 含量升高与乳腺癌远端转移呈正相关，肿瘤标志物 CA15-3 在诊断 乳腺癌远端转移上具有一定的临床意义。 关键词:乳腺癌;远端转移:血脂水平 中图分类号: R 737.9 文献标志码:A 文章编号: 1672-2353(2015)23-D66 -D3 DOI: 10. 7619/jcmp. 201523020 Correlation between distant metastasis of breast cancer and lipid level of peripheral blood CHEN Xiaochun (Department 01 Oncology , Wu.xue First People s Hospital , W阳山，， Hubei , 4354∞) ABSTRACT: Objective To explore the correlation between distant metastasis of breast cancer and lipid level of peripheral blood. Methods Patients with distant metastasis of breast cancer were designed as observation group , and the patients without distant metastasis of breast cancer were de- signed as control group. Results Levels of TC (t =3. 234 , P =O. 002 ), TG (t =4. 111 , P 0.001) ,LDL-C (t =3.361 , P =3.361) in the observation group were significantly higher than those in the control group (P 0.05). Levels of CA125 (t =2. 147 , P =2. 147) and CA15-3 (t =2.272 , P = 2.272) in the observation group were significantly higher than those in the contr