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AdultRostralMigratoryStream.PDF
2704 • The Journal of Neuroscience, March 7, 2007 • 27(10):2704–2717
Development/Plasticity/Repair
1 Integrins Control the Formation of Cell Chains in the
Adult Rostral Migratory Stream
1 1 2 3 1
Richard Belvindrah, Sabine Hankel, John Walker, Bruce L. Patton, and Ulrich Mu¨ller
1The Scripps Research Institute, Department of Cell Biology, Institute for Childhood and Neglected Disease, La Jolla, California 92037, 2Genomic Institute of
the Novartis Research Foundation, San Diego, California 92121, and 3Oregon Health and Science University, Portland, Oregon 97239
The subventricular zone (SVZ) of the lateral ventricle is the major site of neurogenesis in the adult brain. Neuroblasts that are born in the
SVZ migrate as chains along the rostral migratory stream (RMS) to the olfactory bulb. Little is known about the mechanisms that control
interactions between neuroblasts during their migration. Here we show that migrating neuroblasts express 1integrins and that the
integrin ligand laminin is localized to cell chains. Using genetically modified mice and time-lapse video recordings of SVZ explants, we
demonstrate that 1 integrins and laminin promote the formation of cell chains. Laminin also induces the aggregation of purified
neuroblasts. We conclude that the formation of cell chains in the RMS is controlled in part by 1 integrins via binding to laminin. In
addition, we provide evidence that 1 class integrins are required for the maintenance of the glial tubes and that defects in the glial tubes
lead to the ectopic migration of neuroblasts into the surrounding tissue.
Key words: 1 integrins; SVZ; RMS; migration; laminin; CNS
Introduction and Horwitz, 2002; Nguyen-Ba-Charvet et al., 2004; Ng et al.,
Neurons are generated in the adult
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