HemorrhageTheRotterdamStudy.PDF

Serum Lipid Levels and the Risk of Intracerebral Hemorrhage: The Rotterdam Study Renske G. Wieberdink, Marie¨lle M.F. Poels, Meike W. Vernooij, Peter J. Koudstaal, Albert Hofman, Aad van der Lugt, Monique M.B. Breteler, M. Arfan Ikram Objective—Low serum total cholesterol levels are associated with an increased risk of symptomatic intracerebral hemorrhage and with presence of asymptomatic cerebral microbleeds. The relative contribution of lipid fractions to these associations is unclear and requires investigation. We determined whether serum HDL-cholesterol, LDL-choles- terol, and triglycerides are associated with risk of intracerebral hemorrhage and presence of cerebral microbleeds. Methods and Results—Nine thousand sixty-eight stroke-free community-dwelling persons aged 55 were followed from