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I.J. Engineering and Manufacturing, 2016, 4, 1-8 Published Online July 2016 in MECS () DOI: 10.5815/ijem.2016.04.01 Available online at / ijem Big Data in Cyber-Physical Systems, Digital Manufacturing and Industry 4.0 Lidong Wanga,*, Guanghui Wangb aDepartment of Engineering Technology, Mississippi Valley State University, USA bState Key Laboratory of Severe Weather, Chinese Academy of Meteorological Sciences, China Abstract A cyber physical system (CPS) is a complex system that integrates computation, communication, and physical processes. Digital manufacturing is a method of using computers and related technologies to control an entire production process. Industry 4.0 can make manufacturing more efficient, flexible, and sustainable through communication and intelligence; therefore, it can increase the competitiveness. Key technologies such as the Internet of Things, cloud computing, machine-to-machine (M2M) communications, 3D printing, and Big Data have great impacts on Industry 4.0. Big Data analytics is very important for cyber -physical systems (CPSs), digital manufacturing, and Industry 4.0. This paper introduces technology progresses in CPS, digital manufacturing, and Industry 4.0. Some challenges and future research topics in these areas are also presented. Index Terms: Big Data, Big Data Analytics, Cyber-physical System (CPS), Digital Manufacturing, Industry 4.0, Cloud Computing, Internet of Things (IoT), Cybersecurity, 3D Printing, Network-based Systems. © 2016 Published by MECS Publisher. Selection and/or peer review under responsibility of the Research Association of Modern Education and Computer Science . 1. Introduction U.S. has been driving industrial Internet, cyber physica