niea中国药理学覆.PDF

BIBLID．ISSN ActaPh~rmacologicaSiniea 中国药理学覆 Cardiacresponsesactivated by nicotinein canineganglialplexus between aortaand pulm onary artery YUAN Bing—Xiang．REN Hui—M in ，YANG Guang—De，YANG yin-Jing，QILin (DepaPtmentofPharmacology，FacultyofPharmacy， DepartmentofAnatomy，Xi—anMedical University，Xi—an 710061，China) ABSTRACT In order to study the location cardiac ganglia ”． Canine intrinsic cardiac and function ofnicotine—sensitive neuronsof neuronshavebeen identifiedinthefatonboth cardiac ganglialplexuses，m icrodissectionsof theventral，and dorsalsurfacesofatria ’。·”， collections offat padswere carried out，and the cranialsurface of the ventricles and cir— nicotine (100pg)wasinjectedintothegan— cum flex corona ry arteries，and in the origins glial plexus between aorta and pulmonary ofrightand leftmra ginalcoronaryarteries ． artery (A—PGP)in 30anesthetized open—chest aswellasintheganglialplexusbetweenaorta dogs． Therewerenumerousgangliaorneu— and Pulmona ry artery (A—PGP) ． Itwas tons in A—PGP． Either positive ornegative unclearwhethernicotinecan activateneurons inotropic and chronotropic responses were incardiacganglialplexusessothatthecardio— elicited following injections ofnicotine into dynamics would be changed． Furthermore， A—PGP． Controlinjectionsof0．1mlsaline littleisknown aboutthefunction ofnicotine— intoA—PGP andinjectionsofnicotine (100or sensitirecardiacneurons． 200 g)intorightmarginalganglialplexusdid Nicotine activates the efferent post-- notelicitany cardiacresponses． Afteracute ganglionic parasmy pathetic and sym pathetic decentralization，nicotine (100Pg)wasagain neurons，butnotthe intrathoracicautonom ic injectedintothesamelocusofA—PGP． Some