NovelSomaticandGermlineMutationsinCancerCandidate.ppt

Novel Somatic and Germline Mutations in Cancer Candidate Genes in Glioblastoma, Melanoma, and Pancreatic Carcinoma by Asha Balakrishnan, Fonnet E. Bleeker, Simona Lamba, Monica Rodolfo, Maria Daniotti, Aldo Scarpa, Angela A. van Tilborg, Sieger Leenstra, Carlo Zanon, and Alberto Bardelli Cancer Res Volume 67(8):3545-3550 April 15, 2007 ?2007 by American Association for Cancer Research Examples of somatic mutations in EPHA3, TECTA, and OBSCN. Bottom, chromatogram of the sequence of a tumor sample; top, chromatogram of the matched normal. Asha Balakrishnan et al. Cancer Res 2007;67:3545-3550 ?2007 by American Association for Cancer Research Germline mutation in OBSCN. Sequence of the OBSCN gene in sample T1 where the germline mutation R4558H was found. Asha Balakrishnan et al. Cancer Res 2007;67:3545-3550 ?2007 by American Association for Cancer Research Examples of somatic mutations in EPHA3, TECTA, and OBSCN. Bottom, chromatogram of the sequence of a tumor sample; top, chromatogram of the matched normal. Arrows, location of missense somatic mutations. Nucleotide and amino acid alterations are below the traces. Numbers above the sequences are part of the software output. A, EPHA3 mutation in glioblastoma multiforme. B, TECTA mutation in melanoma. C, OBSCN mutation in melanoma. Germline mutation in OBSCN. Sequence of the OBSCN gene in sample T1 where the germline mutation R4558H was found. Bottom, chromatogram of the sequence of the glioblastoma sample; top, chromatogram of the respective matched normal. Arrow, location of the mutation. Nucleotide and amino acid alterations are below the trace. Germline mutation in OBSCN. Sequence of the OBSCN gene in sample T1 where the germline mutation R4558H was found. Bottom, chromatogram of the sequence of the glioblastoma sample; top, chromatogram of the respective matched normal. Arrow, location of the mutation. Nucleotide and amino acid alterations are below the trace.