标准化测量海马体积_张勇.pdf

DOI :10.13929/j.1003 -3289.2010.09.004 2010 26 9 　Chin J M ed Imaging Technol, 2010, Vol 26, No 9 ·1611 · Standard measurement of hippocampal volume 1, 2 1 ＊ 1 3 3 1 ＊ ZHANG Yong , CHEN N an , WAN GX ing , ZH UO Yan , CHEN Lin , LI K un-cheng (1.Dep artment of Ra iology , X uanwu Hosp ital, Cap ital Me ical University , Beij ing 100053, China; 2.Dep artment of Ra iology , Civi l Aviation General Hosp ital, Beij ing 100123, China; 3.StateK ey Laboratory of Brain an Cognitive Science, I nstitute of Biop hysics, ChineseAca emy of Sciences, Beij ing 100101, China) [Abstract]　Objective　To analyze the relationship betw een the hippocampal volume and intracranial volume in healthy Chi- nese adults, in order to provide a reliable correction method of hippocampal volume measurement.Methods 　A total of 1000 healthy Chinese adults, ranging f rom 18 to 6 years-old, underw ent cranial M R scan w ith T 1 w eighted three-dimensional magnetization prepared rapid acquisition gradient echo sequences.Hippocampal volume was measured using manual drawing region of interest with three-dimensional volume analysis software.Intracranial volume w as obtained w hen head height diam- eter w as multiplied by anteroposterior diameter by width.Since the cranial cavity volume and hippocampal volume were rela- tively stable during 18—60 years, 800 adults aged f rom 18 to 60 were selected for volume correction analysis using the divi- sion and covariance method.Then the hippocampal volume in different gender and side in 1000 healthy Chinese adults w as corrected and analyzed by