基于Wntβ-catenin信号通路的结直肠癌研究进展.PDF

生命的化学, 2016, 36(1): 71-80 田慧芹, 等. 基于Wnt/β-信号通路的结直肠癌研究进展 doi: 10.13488/j.smhx 71 · 基于Wnt/β-catenin信号通路的结直肠癌研究进展 1,2 1 1* 田慧芹 ，张倩云，韩秀珍 1 2 ( 山东大学药学院，济南 250012 ； 山东中医药高等专科学校，烟台 264199) 摘要：结直肠癌是临床常见的消化道恶性肿瘤之一，目前以手术为主的治疗手段术后复发率高，寻找 既高效又安全的预防药物成为研究热点。在结直肠癌的发生、发展过程中，Wnt/β-catenin信号通路的 异常激活发挥了重要作用，探索该通路的多种成分和研究它们之间的相互作用机制，有助于开发出针 对该通路特定靶位的有效拮抗剂，为早期防治结直肠癌提出全新的思路。本文就Wnt/β-catenin信号通 路及相关基因和结直肠癌的关系及以Wnt/β-catenin信号通路为靶点的抗结直肠癌药物做一综述。 APC 关键词：Wnt/β-catenin；结直肠癌； 基因；GSK-3β Research progress of Wnt/β-catenin signaling pathway and colorectal cancer 1,2 1 1* TIAN Huiqin , ZHANG Qianyun , HAN Xiuzhen 1 ( Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Ji’nan 250012, China; 2 Shandong College of Traditional Chinese Medicine, Yantai 264199, China) Abstract: Colorectal cancer is one of the common malignant tumors of digestive tract. Surgical treatment is the primary therapeutic method at present but the postoperative recurrence rate is high. Searching for both , effective and safe drug becomes the research hotspot for colorectal cancer prevention. In the process of the occurrence and development of colorectal cancer, the abnormal activation of Wnt/β-catenin signaling pathway plays an important role. To explore a variety of ingredients of the pathway and study the interaction mechanism between them will help develop effective antagonist against the pathway specific