分子医学概论(国外英文资料).doc

分子医学概论 1 molecular medicine? The term molecular medicine was coined by leading scientists in the field of biomedical frontiers in an authoritative magazine and symposium in 1994. In February 1994, the United States national institutes of health (NIH) in the tumor research institute, general ((Karp) and broad ((Broder) in the journal cancer research, published an article called the new direction of molecular medicine lengthy commentary, introduces in detail the main progress of molecular medicine. In September 1994, held in San Francisco organized by the journal nature, molecular medicine seminar, the journal nature on the published essay, titled the challenge of molecular medicine is the influence of the development of medical molecular biology and the problems faced by comments. In 1995, from basic and clinical studies in the field of molecular medicine editorial published in the journal molecular medicine scientists has officially launched, it marks the modern biological medicine has entered the new stage of the molecular medicine. According to the definition of karp, molecular medicine consists of the basic molecule that finds control of normal cellular behavior; To understand the relationship between the abnormal expression of genes and the interactions between genes and disease; These abnormal genes are examined and corrected to diagnose, treat and prevent disease. The main difference between molecular medicine and traditional medicine is that the former is both at the molecular and genetic level. Molecular mechanism of disease 1.1 Rapid development of molecular biology and the medical wide first is in terms of basic research, find out some molecular systems that regulate cell behavior, such as cell signal transduction, the molecular basis of some important structure and function of the enzyme and biological molecules and their encoding genes, cancer protein, tumor-suppressor protein and gene, cell information molecules such as cytokines, neuropeptides, etc. Th