多NER基因多态的交互作用与移植排斥的发病风险相关_王本刚.pdf

Hereditas (Beijing) 2017 1 , 39(1): 2231 NER 1 2 2 1 1. 110001 2. 110001 SNP-SNP SNP (NER) SNP Sequenom MassARRAY 8 NER 38 XPA XPC DDB2 XPB (ERCC3) XPD (ERCC2) ERCC1 XPF (ERCC4) XPG (ERCC5) XPA rs3176629-rs2808668 C-T ERCC5 G-C-C-T G-C-T-C ( OR = 1.81 OR=7.72 OR=3.46) ERCC5 rs2094258-rs751402-rs2296147-rs1047768 A-C-T-T (OR = 0.35) Logistic (MDR) ERCC2 rs50871 ERCC5 rs1047768 XPC rs2228001 SNP-SNP XPC rs2228001 ERCC2 rs50871ERCC5 rs1047768 Interactions among polymorphisms of NER genes prompt the risk of transplantation rejection 1 2 2 1 Bengang Wang , Zhi Lv , Qian Xu , Yongfeng Liu 1. Organ Transplantation Department of General Surgery Institute, the First Affiliated Hospital of China Medical University, She- nyang 110001, China; 2. Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Med- ical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Educa- tion Department, Shenyang 110001, China Abstract: Better efficacy for predicting the risk of transplantation rejection could be achieved by intergenic inter- actions among single nucleotide polymorphisms (SNPs) compared with one SNP. In this study, we explored the fore- warning function of interactions among SNPs in nucleotide excision repair (NER) genes. Thirty-eight polymorphisms in eight NER genes were genotyped by Sequenom MassARRAY platform, including XPA , XPC , DDB2 , XPB (ERCC3), XPD (ERCC2), ERCC1 , XPF (ERCC4), and XPG (ERCC5). The haplotype analysis suggested that XPA rs3176629-rs2808668 C-T and ERCC5 G-C-C-