MRI-三维重建动态测量颅脑创伤模型大鼠的空腔变化.doc

MRI-三维重建动态测量颅脑创伤模型大鼠的空腔变化 符 锋，赵明亮，李晓红，陈 翀，王丽娜，孙洪涛，涂 悦，张 赛(脑创伤与神经疾病研究所，武警后勤学院附属医院脑科医院，天津市神经创伤修复重点实验室，天津市 300162) 引用本文：符锋，赵明亮，李晓红，陈翀，王丽娜，孙洪涛，涂悦，张赛. MRI-三维重建动态测量颅脑创伤模型大鼠的空腔变化[J].中国组织工程研究，2016，20(40):5946-5952. DOI: 10.3969/j.issn.2095-4344.2016.40.003 ORCID: 0000-0002-9296-6296(符锋) 文章快速阅读： 文题释义： 电子脑皮质挫伤撞击仪基于DICOM格式的三维重建技术 基金资助： 国家自然科学基金项目8140106781271392)，中国博士后基金项目(2013M542583) Dynamic changes of brain cavity in rats after traumatic brain injury detected by MRI-based three-dimensional reconstruction Fu Feng, Zhao Ming-liang, Li Xiao-hong, Chen Chong, Wang Li-na, Sun Hong-tao, Tu Yue, Zhang Sai (Institute of Brain Trauma and Neurological Disease, Brain Hospital Affiliated to Logistics University of Chinese People’s Armed Police, Key Laboratory of Neurological Trauma Repair, Tianjin 300162, China) Abstract BACKGROUND: Currently, morphological observations of brain cavity after traumatic brain injury (TBI) via cadavers or animal specimen are difficult to obtain dynamic changes. OBJECTIVE: To explore the application effect of MRI-based three-dimensional (3D) reconstruction for evaluating the prognosis of TBI. METHODS: Five male Sprague-Dawley rats were enrolled to establish TBI models by Electronic Cortical Contusion Injury (eCCI), and scanned by 3.0T MRI with Rat-coil to obtain the DICOM date of brain at 1 day, 1, 2 and 3 months after modeling. Brain cavities were 3-dimensionally reconstructed by Mimics16.0 software, and analyzed in the Meshmixer software. RESULTS AND CONCLUSION: (1) The outline of reconstruction model image was clear, and could be observed and measured from different sides and perspectives. (2) The cavity volume and surface area at different time points after TBI showed significant differences between each other except that at 2 and 3 months (P 0.05). (3) The results of cavity change suggested that the cavity tended to be regular after 3 months of TBI. (4) In conclusion, 3D reconstruction software Mimics combining