免疫05immunoglobulin1.ppt

* * Ig超家族，IgSF 三、抗体片段 免疫球蛋白的水解片段 Fab： fragment of antigen binding Fc: fragment crystallizable * * What you should know in this part Definition of Ab and Ig The basic structure of Ig Ig的基本结构 J链、分泌片 * * 第二篇 免疫分子 Immune Molecules * * 第五章 抗体 Chapter 5 Antibody 抗毒素 Emil von Behring 1854 – 1917 贝林-豚鼠屠夫 Paul Ehrlich 1854-1915 埃尔利希 体液免疫的倡导者 * * The glycoproteins produced by B cells which differentiate to plasma cells in the response to stimulation of antigen are called Abs, they can specifically combine with the corresponding antigen. Antibody (Ab) * * Abs and all globulins that show structural similarities to Abs are called Igs. Therefore, all Abs are Igs, but not all Igs are Abs. Immunoglobulin (Ig) 免疫球蛋白 secreted Ig, sIg （分泌型） membrane Ig, mIg （膜型） Ab BCR * * Antibody, Ab A type of glycoprotein molecule, also called immunoglobulin (Ig), produced by B lymphocytes, that binds antigens, often with a high degree of specificity and high affinity. Humoral immunity 体液免疫 * * 第一节 免疫球蛋白的分子结构 Molecular Structure of Immunoglobulin * * 一“Y”字型的四肽链结构， 有两条相同的重链 和两条相同的轻链 借助二硫键连接而成。 一、免疫球蛋白的基本结构 * * 55 ~ 75 kDa 450 ~ 550 aa 1. Heavy chain and Light chain heavy chain, H light chain, L 25 kD 214 aa * * classes of Ig According to the differences of heavy chains ( amino acid composition, sequence), Igs can be divided into 5 classes: Five classes of H Chain: ?, ?, ?, ?, ? Five classes of Ig : IgG, IgA, IgM, IgD, IgE Subclass: According to differences of the amino acid composition and number or position of disulfide bonds in hinge region: IgG----IgG1, IgG2, IgG3, IgG4 IgA----IgA1, IgA2 铰链区 * * According to differences of the light chains, Igs can be divided into two types: Two types of L chain: ?, ? Subtype: λtype------ λ1, λ2, λ3, λ4 * * Constant region (C): CH, CL Variable region (V): VH, VL Hypervariable region (HVR) 高变区 Framework region (FR) 骨架区 Hinge region 铰链区 N C 2. Vari