丹红注射液治疗糖尿病肾病临床效果和对血小板.doc

丹红注射液治疗糖尿病肾病的临床效果及对血小板 　　[摘要] 目的 探讨丹红注射液治疗糖尿病肾病的临床效果及对血小板CD62p、PAC-1表达的影响。 方法 选取2014年12月～2015年12月河北北方学院附属第一医院收治的糖尿病肾病患者95例，将其随机分为观察组（50例）和对照组（45例）。对照组给予常规降糖、降压、降脂药物治疗，观察组在此基础上加用丹红注射液治疗，治疗2周，观察两组治疗前后血脂、肾功能相关指标，并检测血小板CD62p、PAC-1的表达。 结果 观察组总有效率为90.0%（45/50），对照组总有效率为64.4%（29/45），差异有高度统计学意义（χ2=6.905，P 0.05）。对照组治疗前后总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）比较差异无统计学意义（P 0.05），观察组治疗后TC、TG、LDL-C明显下降，HDL-C明显升高，且与对照组治疗后比较差异有统计学意义（P 0.05）。 结论 丹红注射液可明显抑制糖尿病肾病患者CD62p、PAC-1的表达，减少尿蛋白，降低血脂，改善肾功能 [关键词] 糖尿病肾病；丹红注射液；CD62p；PAC-1；临床疗效 [中图分类号] R587.2 [文献标识码] A [文章编号] 1673-7210（2016）07（a）-0092-04 [Abstract] Objective To investigate the clinical effect of Danhong Injection in the treatment of diabetic nephropathy and its influence on the expression of platelet CD62p， PAC-1. Methods Ninety five cases with diabetic nephropathy admitted to the First Affiliated Hospital of Hebei North University from December 2014 to December 2015 were selected and randomly divided into the observation group （50 cases） and the control group （45 cases）. The patients in the control group were treated by conventional hypoglycemic， hypotensive and lipid-lowering drugs， while the patients in the observation group were treated by Danhong Injection on the basis of conventional therapy for 2 weeks. The blood lipid， renal function indexes of the two groups before and after treatment were observed， and the expression of platelet CD62P and PAC-1 were detected. Results The total effective rate of the observation group was 90% （45/50）， the total effective rate of the controlk group was 64.4% （29/45）， and the difference was highly statistically significant （χ2=6.905，P 0.05）. There were no significant differences of total cholesterol （TC）， triacylglycerol （TG）， high density lipoprotein cholesterol （HDL-C） and low density lipoprotein cholesterin （LDL-C） before and after treatment in the control group （P 0.05）. After treatment， TC， TG and LDL-C in the observation group were decreased significantly， HDL-C w