乳酸杆菌活菌制剂治疗阴道炎效果和安全性探析.docVIP

乳酸杆菌活菌制剂治疗阴道炎效果和安全性分析 　　【摘要】目的：探讨乳酸杆菌活菌制剂治疗阴道炎的有效性及安全性。方法：选取344例阴道炎患者随机均分为观察组和对照组，观察组采用甲硝唑联合乳酸杆菌活菌制剂治疗，对照组采用甲硝唑治疗，比较两组临床疗效、不良反应发生及随访期间复发情况。结果：观察组细菌性阴道病、念珠菌性阴道炎及滴虫性阴道炎痊愈率和有效率均明显高于对照组，治疗后3、6、9个月复发率低于对照组，差异具有统计学意义（P0.05），两组不良反应发生率差异无统计学意义（P0.05）。结论：乳酸杆菌活菌制剂治疗阴道炎患者安全有效，可在临床上推广 【关键词】乳酸杆菌活菌制剂；阴道炎；有效性；安全性 Efficacy and safety analysis of live lactobacillus preparation in patients with vaginitisSHI Jianrong1， HUANG Qingyi2， YANG Rui2. 1.Department of Gynecology and Obstetrics， Jiyuan Hospital of Chinese Traditional Medicine， Jiyuan 454650， Henan， China； 2. Department of Gynecology and Obstetrics，Nanyang Central Hospital， Nanyang 473002， Henan， China 【Abstract】Objectives： To explore the efficacy and safety of live lactobacillus preparation in patients with vaginitis. Methods： 172 patients with vaginitis were randomly divided into observation group and control group. Observation group received the treatment of metronidazole combined with live lactobacillus preparation and control group was treated with metronidazole. The clinical efficacy， adverse reactions and recurrence of two groups were compared. Results： The recovery rate and efficiency of bacterial vaginitis， candida vaginitis and trichomonas vaginitis of observation group were significantly higher than these in control group. The recurrence rate of the 3， 6 and 9 months after treatment in observation group were lower than these in control group， with statistically significant difference （P0.05）， without significant difference in the incidence of adverse reactions between two groups （P0.05）. Conclusion： The treatment of live lactobacillus preparation in patients with vaginitis is safe and effective， which can be applied in clinical practice. 【Key words】Live lactobacillus preparation； Vaginitis： Efficacy； Safety 【中图分类号】R711.31【文献标志码】A 阴道炎属于一种常见的妇科疾病，是病原微生物感染引起的多种阴道黏膜疾病的总称，常见病原体包括细菌、念球菌、阴道毛滴虫及支原体等。其发生机制主要为阴道菌群失调，尤其是可产生H2O2的乳酸杆菌急剧减少或消失，厌氧菌群异常增加[1]。临床研究表明，多种病原微生物均可引起阴道炎，治疗阴道炎的关键是重建阴道微生态系统，改善阴道防御能力，提高临床疗效，降低复