益生菌对术后结肠直肠癌病人肠道黏膜屏障地影响：随机对照实验分析.pdf

® Medicine SYSTEMATIC REVIEW AND META-ANALYSIS Effects of Probiotics on Intestinal Mucosa Barrier in Patients With Colorectal Cancer after Operation Meta-Analysis of Randomized Controlled Trials Dun Liu, Xiao-Ying Jiang, Lan-Shu Zhou, MD, PhD, Ji-Hong Song, and Xuan Zhang, MD Abstract: Many studies have found that probiotics or synbiotics can be However, to evaluate the protective effect on intestinal mucosal barrier, used in patients with diarrhea or inflammatory bowel disease for the further studies on the type and concentration of the probiotics, duration of prevention and treatment of some pathologies by improving gastrointes- therapy, and the therapeutic route are required. tinal barrier function. However, there are few studies availing the use of (Medicine 95(15):e3342) probiotics in patients with colorectal cancer. To lay the foundation for the study of nutritional support in colorectal cancer patients, a meta-analysis Abbreviations: B/E = Bifidobacterium to Escherichia, CRP = C- has been carried out to assess the efficacy of probiotics on the intestinal reactive protein, IL-6 = interleukin 6, L/M = lactulose to mannitol, mucosa barrier in patients with colorectal cancer after operation. RCT = randomized controlled trial, SIgA = secretory To estimate the efficacy of probiotics on the intestinal mucosa barrier immunoglobulin A, TNF = tumor necrosis factor. in patients with colorectal cancer after operation, a meta-analysis of randomized controlled trials has been conducted. Databases including PubMed, Ovid, Embase, the Cochrane Central