DPP DPPOS成本效益.pdf

E p i d e m i o l o g y / H e a l t h S e r v i c e s R e s e a r c h O R I G I N A L A R T I C L E The 10-Year Cost-Effectiveness of Lifestyle Intervention or Metformin for Diabetes Prevention An intent-to-treat analysis of the DPP/DPPOS THE DIABETES PREVENTION PROGRAM the long-term effects of the interventions RESEARCH GROUP* on health. The DPPOS has followed participants for an additional 7 years during which time OBJECTIVEdThe Diabetes Prevention Program (DPP) and its Outcomes Study (DPPOS) participants in lifestyle and metformin were demonstrated that either intensive lifestyle intervention or metformin could prevent type 2 di- encouraged to continue those interven- abetes in high-risk adults for at least 10 years after randomization. We report the 10-year within- tions, and all participants were offered a trial cost-effectiveness of the interventions. group lifestyle intervention (4). The inci- RESEARCH DESIGN AND METHODSdData on resource utilization, cost, and quality dence of diabetes during the 10-year average of life were collected prospectively. Economic analyses were performed from health system and follow-up after randomization was reduced societal perspectives. by 34% in those initially randomized to life-