STRING v10：protein–protein interaction networks, integrated over the tree of life.pdf

Published online 28 October 2014 Nucleic Acids Research, 2015, Vol. 43, Database issue D447–D452 doi: 10.1093/nar/gku1003 STRING v10: protein–protein interaction networks, integrated over the tree of life 1 1 1 2 Damian Szklarczyk , Andrea Franceschini , Stefan Wyder , Kristoffer Forslund , Davide Heller1 2 1 1 3 , Jaime Huerta-Cepas , Milan Simonovic , Alexander Roth , Alberto Santos , Kalliopi P. Tsafou3 , Michael Kuhn4,5 , Peer Bork2,* , Lars J. Jensen3,* and Christian von Mering1,* 1 Institute of Molecular Life Sciences and Swiss Institute of Bioinformatics, University of Zurich, 8057 Zurich, Switzerland, 2 European Molecular Biology Laboratory, 69117 Heidelberg, Germany, 3 Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, 2200 Copenhagen N, Denmark, 4 Biotechnology Center, Technische Universitat Dresden, 01062 Dresden, Germany and 5 Max Planck Institute of Molecular Cell Biology and ¨ Genetics, 01062 Dresden, Germany Received September 15, 2014; Accepted October 07, 2014 ABSTRACT INTRODUCTION The many functional partnerships and interactions For a full description of a protein’s function, knowledge that occur between proteins are at the core of cel- about its speciic interaction partners is an important pre- lular processing and their systematic characteriza- requisite. The concept of protein ‘function’ is somewhat hi- tion helps to provide con