诺丽果粉食用安全性研究_林卫华.pdfVIP

中国热带医学2011 年第11 卷第12 期 CHINA TROPICAL MEDICINE Vol . 11 No .12 December 2011 1509 实验研究 诺丽果粉食用安全性研究 林卫华，郑定仙，冯丁山，王湛，黄业宇，吴爱琴 摘要：目的 对诺丽果粉的毒性和致突变性进行探讨，了解其食用安全性。 方法 采用急性毒性试验、骨髓细胞 微核试验、小鼠精子畸形试验、Ames 试验、30d 喂养试验进行检测。 结果 诺丽果粉雌雄小鼠经口MTD＞10.0g/kg 体 重，属实际无毒级物质；骨髓细胞微核试验、小鼠精子畸形试验、Ames 试验均为阴性，30d 喂养试验中体重和食物利用 率、血液学指标均无异常，生化学指标在正常值范围内，主要器官未见病理学改变。 结论 诺丽果粉无明显毒性。 关键词：诺丽；毒性；安全性 中图分类号：R-33 文献标识码：A 文章编号：1009-9727 （2011）12-1509-03 Study on safety of Noni Fruit Powder. LIN Wei-hua ，ZHENG Ding-xian ，FENG Ding-shan ，et al. （Hainan Provincial Centor for Desease Prevention and Control ，Haikou 570203，China） Abstract ：Objective Study on toxicity and mutagenecity of Noni fruit powder to assess its safety. Methods Acute Toxicity Test ，Bone Marrow Cell Micronucleus Test ，Mice Sperm Abnormality Test ，Ames test and Thirty Days Feeding Test were performed. Results The MTD in mice was over 10.0g/kg.bw. that showed Noni fruit powder was belong to the nontoxic. Negative results were revealed in Bone Marrow Cell Micronucleus Test and Mice Sperm Abnormality Test as well as in Ames test. Furthermore ，in Thirty Feeding Test ，nosignificant differences were found in bodyweight ，food efficiency and blood endpoint values between test groups and control group. The values of serum biochemical separately fell into the ranges of the normal specific concentrations. An absence of histological changes in rat organs was observed. Conclusion Nonadverse effects of Noni fruit powder were observed in this study. Key word ：Noni; Toxicity; Safety 诺丽（Morinda Citrifolia L. ，Noni），属茜草科巴戟天属植 养箱、CL- 8000 全自动生化分析仪、MEK- 6318K 血液分析仪。 物，为热带常绿多年生灌木。主要生长于南太平洋岛屿、澳大利 1.2 方法[1]