土壤中氟喹诺酮类药物残留的生态效应及归宿.PDF

微生物学通报 JAN1) 94~97 Microbiology ©2008 by Institute of Microbiology, CAS tongbao@ 专论与综述 土壤中氟喹诺酮类药物残留的生态效应及归宿 高元钢 1 向云彬1 陈京元 2 余知和 1* (1. 434025) (2. 430079) 摘 要: 氟喹诺酮类药物是人工合成的高效广谱抗菌药, 对细菌的 DNA 螺旋酶具有选择性抑制 作用, 因其具有良好的药物动力学特性及治疗效果, 临床应用非常广泛, 但同时也引起环境污染。 本文综述了氟喹诺酮类药物的理化特性及其对环境的影响, 土壤中残留氟喹诺酮类药物的检测以 及氟喹诺酮类药物污染土壤的生物修复。 关键词: 抗生素, 环境污染, 生物降解, 土壤分析 Ecological Effects and Fate of Fluoroquinolones Residues in Soil GAO Yuan-Gang1 XIANG Yun-Bin 1 CHEN Jing-Yuan2 YU Zhi-He 1* (1. College of Life Science, Yangtze University, Jingzhou 434025) (2. Hubei Academy of Forestry , Wuhan 430079) Abstract: Fluoroquinolones are synthetic antimicrobial agents that are active against a broad spectrum of pathogenic Gram-negative and -positive bacteria by selectively inhibiting DNA gyrase and used in a wide variety in clinic because of their good pharmic kinetics and curing effects, thus causing environmental pollu- tion. The physicochemical characteristics of fluoroquinolones and their environmental effect, identification, monitoring and bioremediation in soil were summarized in this paper. Keywords: Antibiotic, Environmental pollution, Biodegradation, Soil analysis 10 , , , , [1, 4] , (ecotoxicity) , (quinolones) , (fluoroquinolones) [1−3] , , [5] 4- , , , 1962 , [6] 20