新型功能性MRI造影增强剂.pdf

ORIGINAL ARTICLE Renal Functional Contrast-Enhanced Magnetic Resonance Imaging Evaluation of a New Rapid-Clearance Blood Pool Agent (P792) in Sprague-Dawley Rats Damien Mandry, MD,* Michael Pedersen, PhD,† Freddy Odille, MS,* Philippe Robert, PhD,‡ Claire Corot, PhD,‡ Jacques Felblinger, PhD,* Nicolas Grenier, MD,§ and Michel Claudon, MD* with P792 (time to maximal enhancement (sec)/ enhancement rate: Objectives: The objective of the present study was to compare 85.5 15.9/3.1 0.4) as compared with Gd-DOTA full (53.0 P792, a new rapid clearance blood pool agent characterized by 18.9/ 2.7 0.3) or half dosage (65.2 20.1/ 2.2 0.2). The negligible interstitial diffusion but unrestricted glomerular filtration, subsequent decrease in signal intensity, characterized by a down- with Gd-DOTA in both qualitative and quantitative aspects of renal slope during the minute following maximal enhancement, was faster functional magnetic resonance imaging. with Gd-DOTA (0.006 0.002) as compared either to P792 or half Materials and Methods: Dynamic imaging was performed with a dosage Gd-DOTA (0.003 0.001). fast T1-weighted gradient-echo sequence on a 1.5-T magnet in 25