2型糖尿病治疗药物研究进展-王涛.pdf

PROGRESS IN PHARMACEUTICAL SCIENCES 2016,40 5 :323-330 ( ) 323 2型糖尿病治疗药物研究进展 王涛 1 ，印晓星2, 3* （1. 徐州医科大学附属医院药学部，江苏 徐州 221002；2. 徐州医科大学药学院临床药理学教研室，江苏 徐州 221004; 3. 江苏省新药研究与 临床药学重点实验室，江苏 徐州 221004） 2 型糖尿病（T2DM）是一种代谢障碍性疾病。传统抗糖尿病药物具有不同程度的副作用，如低血糖、胃肠道反应、体重增加、 [摘要] 心血管风险等，因此开发作用于新靶点和新作用机制的 T2DM 治疗新药成为当前研究的热点。目前基于新靶点设计的糖尿病治疗新药有 些已上市，且获得良好的降糖效果，但大部分药物仍处于临床或临床前研究阶段，其疗效和安全性有待进一步临床验证。综述传统抗糖 尿病药物、T2DM 药物新靶点及基于新靶点设计的抗糖尿病新药的研究进展。 2 型糖尿病；传统抗糖尿病药物；作用机制；治疗靶点 [关键词] R977.15 A 1001-5094（2016）05-0323-08 [中图分类号] [文献标志码] [文章编号] Advances in Therapeutics of Type 2 Diabetes Mellitus 1 2, 3 WANG Tao , YIN Xiaoxing (1. Department of Pharmacy, the Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China; 2. Department of Clinical Pharmacology, Xuzhou Medical University, Xuzhou 221004, China; 3. Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou 221004, China) Type 2 diabetes mellitus (T2DM) is a metabolic disorder. Traditional anti-diabetics frequently lead to various side effects, such as [Abstract] hypoglycemia, gastrointestinal tract reaction, weight gain and cardiovascular risk. Therefore, development of T2DM therapeutics acting on new target through new mechanism has become the focus of current research. Among those anti-diabetics designed against new target, some have reached the market and shown satisfactory hypoglycemic effect, whereas the large majority are still at the stage of pre-clinical and clinical development and subject to further investigations on their efficacy and s