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18 5 Vol. 18, No. 5
2006 10 Chinese Bulletin of Life Sciences Oct., 2006
1004-0374(2006)05-0467-06
GPR40
201203
G 40(GPR40)
GPR40
GPR40
GPR40
G P R 4 0
R587.1; R977.15 A
GPR40 – a potential target for diebete mellitus
GONG Zhen, HE Ling-Yan, LIU Hong, LIU Jing-Gen, ZHU Wei-Liang*, CHEN Kai-Xian, JIANG Hua-Liang
(Drug Discovery and Design Centre, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences,
Chinese Academy of Sciences, Shanghai 201203, China)
Abstract: GTP-binding protein coupling receptor 40(GPR40), which belongs to GPCR superfamily with seven
transmembrane spanning helical bundles, is a potential drug target for diabetes mellitus. It was found that the
receptor can amplify the glucose stimulated insulin secretion (GSIS) by free fatty acid (FFA), and is related to
some neural diseases and cancers. Agonists and antagonists of GPR40 are under research with the aim to
develop new drugs. In the present article, a proceeding of the recent researches on GPR40 has been reviewed,
especially about the molecular mechanism of FFA amplifying GSIS. Furthermore, some other physiological
functions of GPR40 have also been discussed.
Key words: diabetes; insulin; GPR40; free fatty acid
2 [1]
380
2030 4 [2]
320
(WHO)
3 000 120
1.772025
3.7
2003
2006-01-06 2006-04-03
05JC14092
( 1 9 8 0 ) ( 1 9 8 2 ) ( 1 9 7 0 )
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