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Journal of Thrombosis and Haemostasis, 6: 54–61 ORIGINAL ARTICLE The Residual Platelet Aggregation after Deployment of Intracoronary Stent (PREDICT) score T . G E I S L E R , * D . G R A ß , * B . B I G A L K E , * K . S T E L L O S , * T . D R O S C H , * K . D I E T Z , C . H E R D E G * and M . G A W A Z * *Medizinische Klinik III/Cardiology Department, University Hospital Tu¨bingen, Tu¨bingen; and Department of Medical Biometry, University Tu¨bingen, Tu¨bingen, Germany To cite this article: Geisler T, Graß D, Bigalke B, Stellos K, Drosch T, Dietz K, Herdeg C, Gawaz M. The Residual Platelet Aggregation after Deployment of Intracoronary Stent (PREDICT) score. J Thromb Haemost 2008; 6: 54–61. Keywords: aggregation, clopidogrel, clopidogrel resistance, Summary. Background: Recent studies suggest a high interin- coronary artery disease, platelets. dividual variability of response to clopidogrel associated with adverse cardiovascular outcome. Different clinical factors are Introduction considered to influence a persistent residual platelet aggregation (RPA) despite conventional antiplatelet therapy. Objectives: Persistent residual platelet activity after coronary stent implan- To investigate clinical factors that affect RPA after 600-mg tation plays a major role in the cardiovascular outcome after clopidogrel loading in a large unselected cohort of patients with percutaneous coronary intervention (PCI) [1–3]. Although the symptomatic CAD. Methods: The study population included a benefit of additional platelet inhibition with clopidogrel in consecutive cohort of 1092 patients treated with coronary terms of risk reduction for adverse cardiovascular events has stenting for stable