营养性贫血(英文)资料.pptVIP

NUTRITIONAL IRON DEFICIENCY ANEMIA Jie Yu MD. Professor The Department of Pediatrics Hematology/Oncology, Children’s Hospital CONTENTS INDUCTION IRON METABOLISM ETIOLOGY /PATHOGENESIS MANIFESTATIONS LABORATORY FINDINGS DIAGNOSIS DIFFERENTIAL PREVENTION TREATMENT INTRODUCTION Definition / describing The anemia caused by insufficient dietary iron uptake, in which the iron storage and hemoglobin synthesis decreased. INTRODUCTION Clinical characteristics ? iron stores ? serum iron ?hemoglobin concentration , hypochromic microcytic anemia, good response to iron therapy. 6mo to 3 yrs. Incidence IRON METABOLISM CONTENTS New born 75mg/kg Children35-70mg/kg Adults M 50mg/kg F 35mg/kg CMOPARTMENT Hemoglobin 64% Storage iron 30% ferritin hemosiderin Myloglobin 3% Enzyme iron 0.4% Serum iron 0.4% IRON METABOLISM Iron sources Hemoglobin iron Dietary iron IRON METABOLISM Dietary iron High in iron Red meat/ liver kidney/ oily fish Average iron Beans / fortified cereals/ dark green vegetables/ dried fruit/ nuts and seeds Poor in iron milk IRON METABOLISM Iron absorption general absorption 1-20% Meat/ fish/ chicken 10-25% Cereals/vegetables 1% Breast/cow’s milk 50%/10% ABSORPTION TRANSPORT Hemoglobin iron non hemoglobin iron gastric juice proteinase proteolytic HCl heme ferric hemolytic ferric reductase *Vit C ferrous duodenum upper jujenum ferric mucosal cells transferrin* circulation GI tract liver /spleen marrow (fig2) IRON METABOLISM IRON METABOLISM Iron stores and utilizing IRON