中药毒性评价的技术方法及应用_江振洲.pdf

中药毒性评价的技术方法及应用_江振洲.pdf

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rogress in harmaceutical ciences 2013,3377 11 :545-554 545545 Technical Methods and Application of Traditional Chinese Medicine Toxicity Evaluation 1,2 1 1,2 1,3 1,3 1 1,2 JIANG Zhenzhou , WANG Xinzhi , SUN Lixin , WANG Tao , ZHANG Pinghu , HUANG Xin , ZHANG Luyong (1. Jiangsu Center for Drug Screening, China Pharmaceutical University, Nanjing 210009, China; 2. Key Laboratory of Drug Quality Control and Pharmacovigilance(China Pharmaceutical University), Ministry of Education, Nanjing 210009, China; 3. Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, China) Although the safety of traditional Chinese medicine (TCM) has gained widespread concern and attention in recent years, the corresponding theoretical and experimental studies have not been suicient. The toxicity of TCM is one of the key problems in safety. To solve this critical problem, we could refer to the international practices, the western botanical medicine researches, the basis of the theory of TCM, the application of modern technologies and new methods, the results of basic research and the development of appropriate evaluation system and research specii cation. In this paper, we outlined the outcomes of the recent technical methods and applied research related to the evaluation of the toxicity of TCM to provide theoretical basis for TCM toxicity evaluation and technical guidelines, which could also provide research demonstration for typical toxic TCM, such asTripterygium wilfordii as well as promote the development of TCM toxicity studies. TCM toxicity; toxicity evaluation model; hepatotoxicity; neph

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