重要 procollagen trafficking, processing and fibrillogenesis.pdf

Commentary 1341 Procollagen trafficking, processing and fibrillogenesis Elizabeth G. Canty and Karl E. Kadler Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK (e-mail: elizabeth.g.canty@manchester.ac.uk; karl.kadler@manchester.ac.uk) Journal of Cell Science 118, 1341-1353 Published by The Company of Biologists 2005 doi:10.1242/jcs.01731 Summary Collagen fibrils in the extracellular matrix allow connective metalloproteinases, and the directional deposition of fibrils tissues such as tendon, skin and bone to withstand tensile involving the plasma membrane and late secretory forces. The fibrils are indeterminate in length, insoluble pathway. Fibril-associated molecules are targeted to the and form elaborate three-dimensional arrays that extend surface of collagen fibrils, and these molecules play an over numerous cell lengths. Studies of the molecular basis important role in regulating the diameter and interactions of collagen fibrillogenesis have provided insight into the between the fibrils. trafficking of procollagen (the precursor of collagen) through the cellular secretory pathway, the conversion of procollagen to collagen by the procollagen Key words: Procollagen, Collagen, Fibrillogenesis, ECM e c n Introduction collagen type. To date, 27 different collagen types have been e i Collagen fibril