短讯：吡喹酮治疗标准失败在2个返回旅行者血吸虫感染。.pdf

Am. J. Trop. Med. Hyg., 74(2), 2006, pp. 342–344 Copyright © 2006 by The American Society of Tropical Medicine and Hygiene SHORT REPORT: FAILURE OF STANDARD TREATMENT WITH PRAZIQUANTEL IN TWO RETURNED TRAVELERS WITH SCHISTOSOMA HAEMATOBIUM INFECTION DAVID ALONSO,* JOSE MUÑOZ, JOAQUIM GASCÓN, MARIA EUGENIA VALLS, AND MANUEL CORACHAN International Health Center, e Servicio de Microbiología Centro de Diagnóstico Biomédico Clínic, Institut d’Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain Abstract. A single 40 mg/kg dose of praziquantel (PZQ) continues to be the standard treatment for schistosomiasis caused by S. mansoni and S. haematobium in all clinical settings. Experimental development of drug resistance and the recent isolation of S. mansoni strains with a natural tolerance to high doses of PZQ have raised concerns over the adequacy of such a dose. We describe two Spanish travelers with genitourinary schistosomiasis caused by S. haemato- bium in whom repeated standard treatment failed to clear the infection. INTRODUCTION Barcelona, Spain. The results of a physical examination were normal. Hematologic testing showed an absolute eosinophilic Praziquantel (PZQ) is the current drug of choice for schis- 3 count of 750 cells/mm . Two blood cultures and a thick smear tosomiasis. It has few and mild side effects, an affordable were negative. The fever