药物研发过程中药学信息的利用.pdf

·药师之友· 药物研发过程中药学信息的利用Δ ＊ 阿丽塔 ，许培扬，孙灵芝（中国医学科学院医学信息研究所，北京市 100005） 中图分类号 R95 文献标识码 A 文章编号 1001-0408（2011）05-0466-03 摘 要 目的：方便药学科研人员获取药学信息，提高药物研发的效率。方法：在分析药物研发流程的基础上，按项目调研数据 库、临床前研究数据库、临床研究数据库、药物评审信息数据库等4方面对国内、外药学数据库资源进行系统调研。结果与结论： 项目调研数据库主要包括Pharmaproject 数据库等事实型数据库，临床前研究数据库主要包括美国生物医学文献数据库等文摘型 数据库，临床研究数据库主要包括Clinical T 数据库等，药物评审信息数据库主要包括欧洲药品审评管理局等信息数据 库。如果药学科研工作站掌握了相关的药学数据库资源，就能快速准确地检索到需要的信息，从而提高药物研发的效率。 关键词 药物研发；药学数据库；信息利用 Application of Pharmaceutical Information Resource in the Pharmaceutical Research and Development A Li-ta ，XU Pei-yang ，SUN Ling-zhi （Institute of Medical Information ，Chinese Academy of Medical Scienc- es ，Beijing 100005，China ） ABSTRACT OBJECTIVE ：To improve pharmaceutical researcher ’s ability to obtain pharmaceutical information ，and to acceler- ate pharmaceutical research and development. METHODS ：First of all we systemically analyzed the process of pharmaceutical re- search and development ，and then we made comprehensive investigation of domestic and foreign pharmaceutical databases in re- spects of project research database ，pre-clinical research database ，clinical research database and pharmaceutical review information database. RESULTS CONCLUSIONS ：Project research database mainly include fact database such as Pharmaproject database. Pre-clinical research database mainly include abstract database such as biomedical literature database. Clinical research database mainly include ClinicalTrial database ，etc. Pharmaceutical review information database mainly include Europe pharmaceutical evalu- ation administration. If pharmaceutical researcher master relevant pharmaceutical database ，they could rapidly retrieve the informa- tion they want ，and the efficiency of pharmaceutical research can be improved. KEY WORDS Pharmaceutical research and development ；Pharmaceutical databases ；Application of information