氯霉素在尼罗罗非鱼血浆中的药代动力学研究.pdf

29 1 Vol.29, No. 1 2005 2 JOURNAL OF FISHERIES OF CHINA Feb., 2005 : 1000- 0615(2005) 01- 0060- 06 杨先乐, 湛 嘉, 胡 鲲 ( E, , , 200090) - 1 :(RTHPLC) , 50 mg!kg ,, RTHPLC - 1 ,, 0. 25,2.5 12.5 g!mL ,3(90.47 ∀ 3.42) % , 10% ; , 1. 199% 1. 770% , , ,26# T1/ 2 ka 18# 1/ 3,T T , T 18# ,CLs 18# 1.74 ; 1/2 1/ 2 p , , , (AUC) CAP , CAP , , : ; ;; ; :R912; S948 :A The comparative pharmacokinetics of chloramphenicol in Oreochromis niloticus YANG Xianle, ZHAN Jia, HU Kun (EInstitute of Shanghai Municipal Education Commission, Key Laboratory of Aquatic Genetic esources and Aquaculture Ecology Certfi icated by Ministry of Agriculture, Fishery Pathogen Collection of the Ministry of Agriculture, Shanghai Fisheries University, Shanghai 200090, China) Abstract:A high performance liquid chromatography (RTHPLC) method for detection of chloramphenicol ( CAP) in the plasma of nile tilapia ( Oreochomia niloticus) was described and the effect of different water temperatures ( 18# and 26# ) and age of fish ( 1 year old and 2 years old) on the pharmacokinetics of CAP in nile tilapia after oral administration at a single dosage of 50 mg!kg- 1 body weight was examined in this study. The results showed that with RTHPLC base line was smooth and the object peak of the drug