华蟾素胶囊治疗癌性疼痛的临床疗效观察_杨新波.pdf

478 Chinese Journal of Medicinal Guide 2014 Volume 16 No.3 (Serial No.125) 华蟾素胶囊治疗癌性疼痛的临床疗效观察 杨新波 (解放军总医院老研所药理研究室, 北京 100853) 【摘要】目的:探讨华蟾素胶囊对癌性疼痛的临床疗效。方法:将我院治疗的63例恶性肿瘤患者随机分为治疗组33例和西药组30 例,西药组采用口服硫酸吗啡,治疗组口服华蟾素胶囊,对比两组治疗癌性疼痛的效果、不良反应发生率、起效时间、生活质量以及 KPS和NRS评分。结果:治疗组的总有效率为93.9%,西药组为86.7%,两组无统计学差异(P0.05);治疗组平均起效时间为( 11.4 ±4.7) min,西药组为(29.6 ±5.6 1)min,两组相比,具有统计学差异(P 0.05);治疗后两组体重相比,治疗组体重增加率为87.9%,高于西药组 60.0%(P0.05) 。两组KPS评分和NRS评分相比,无统计学差异(P0.05) 。结论:华蟾素对癌性疼痛效果明显,起效快,不良反应低。 【关键词】华蟾素;癌性疼痛;疗效观察 【中图分类号】R969 【文献标识码】A 【文章编号】1009-0959(2014)03-0478-03 Observation on the Clinical Therapeutic Effect of Cinobufacin Capsules in the Treatment of Cancer Pain Yang Xin-bo (Institute of Geriatrics, Chinese PLA General Hospital, Beij ing 100853, China) 【 】 To explore the clinical efficacy of cinobufacini Capsule on cancer pain . Select 63 cases of ABSTRACT Objective: Methods: patients with malignant tumor in our hospital, were randomly divided into treatment group 33 cases and western medicine group of 30 cases,western medicine group were treated with oral administration of morphine sulfate, treatment group was treated with cinobufacini capsule.Comparing the two groups in the treatment of cancer pain effect, adverse reaction incidence, onset time, quality of life as well as the KPS and NRS score.Results: The total effective rate in treatment group was 93.9%, control group 86.7%, two groups had no significant difference (P0.05).The average onset time of treatment group was (11.4 ±4.7) min, the western medicine group (29.6 ±5.61