我院1220例药品不良反应报告分析_朱建国.pdf

我院1220例药品不良反应报告分析 ＊ # 朱建国 ，高 杰，缪丽燕（苏州大学附属第一医院药剂科，苏州市 215006） 中图分类号 R969.3 文献标识码 C 文章编号 1001-0408（2011）38-3604-04 摘 要 目的：探讨我院药品不良反应（ADR ）工作存在的问题及持续改进措施。方法：对我院2009－2010年上报的1220例ADR 报告，分别按患者年龄与性别、报告人职业、引起ADR 的药品种类、临床表现、给药途径等方面进行回顾性统计、分析。结果：1220 例ADR 报告中，严重的和新的ADR76例（6.23％），医师和护士上报仅63例（5.16％），住院患者ADR 发生率低（0.81％）；抗微生物 药引起的ADR 最多，有574例（占47.05％）；ADR 临床表现以皮肤及其附件损害、消化系统反应等主观表现为主。结论：临床应完 善医、药、护合作的ADR 监测体系，提高医师和护士的上报比例；加强严重的、新的ADR 监测，降低漏报率；结合科研采取合适的 手段，发挥临床药师用药监护的作用，以减少可以预见的ADR 发生。 关键词 药品不良反应；报告；分析；存在问题 Analysis of 1220ADR Reports in Our Hospital ZHU Jian-guo ，GAO Jie ，MIAO Li-yan （Dept. of Pharmacy ，The First Affiliated Hospital of Soochow Universi- ty ，Suzhou 215006，China ） ABSTRACT OBJECTIVE ：To investigate the problems and improvement measures of ADR monitoring in our hospital. METH- ODS ：1220ADR reports collected from our hospital from 2009 to 2010 were analyzed retrospectively in respects of patient ’s age and gender ，occupation of reporter ，species of ADR-inducing drug ，clinical manifestations ，route of administration ，etc. RE- SULTS ：Among 1 220ADR cases ，there were 76 serious and new ADR cases （6.23％），only 63 cases were reported by doctors and nurses （5.16％）. A small number of inpatients suffered from ADR （0.81％）. 574 cases were caused by antimicrobial drugs （47.05％）. The clinical manifestations of ADR were based on subjective performance such as lesions of skin and its appendants and digestive system reaction. CONCLUSION ：It is suggested that the doctor ，pharmacist and nurse work together to improve the ADR monitoring system. We should increase the proportion of the ADR reported by the doctor and nurse. The serious and new ADR are strongly monitored. We must reduce the false negative rate of ADR. The appropriate measures with scientific research are adopted and the role of clinica