长江流域5城市42家医院2010_2011年核苷类抗乙型肝炎病毒药利用分析.pdf

长江流域5城市42家医院2010－2011年核苷类抗乙型肝炎病毒药利用分析 ＊ # 刘 荣 ，孟现民，董 平（上海市公共卫生临床中心药剂科，上海 201508） 中图分类号 R969.3；R287 文献标志码 C 文章编号 1001-0408（2013）30-2806-03 DOI 10.6039/j.issn. 1001-0408.2013.30.07 摘 要 目的：了解长江流域医院核苷类抗乙型肝炎病毒（HBV ）药的应用情况及趋势，为临床合理用药提供参考。方法：采用销 售金额排序、限定日剂量（DDD ）、用药频度（DDDs ）排序、取药量/处方数比值法，对长江流域5城市42家医院2010－2011年核苷 类抗HBV 药的应用情况进行统计分析。结果：在使用核苷类抗HBV 药的患者中，上海市以≥45岁的中老年患者为主，其他城市 以18～44岁的青壮年为主，男女患者比例为2.81 1∶；各种核苷类抗HBV 药的使用呈现较大差异，阿德福韦酯和恩替卡韦占据了 70％以上的市场份额。结论：各城市医院2010－2011年核苷类抗HBV 药的销售品种和数量均呈增长态势，但个别品种处方超量 现象较普遍，需规范该类药的使用，特别需要控制患者用药的日均费用和取药量/处方数比值。 关键词 核苷类抗乙型肝炎病毒药；药物应用；限定日剂量；用药频度；合理用药 Analysis of the Utilization of Nucleosides Anti-hepatitis B Virus Agents in 42 Hospitals from 5 Cities in Yangtze River Valley during 2010－2011 LIU Rong ，MENG Xian-min ，DONG Ping （Dept. of Pharmacy ，Shanghai Public Health Clinical Center ，Shang- hai 201508，China ） ABSTRACT OBJECTIVE ：To investigate the utilization and trend of nucleoside anti-hepatitis B virus （HBV ）agents in the hospi- tals from Yangtze River valley ，and to provide reference for rational use of drugs. METHODS ：The utilization of nucleoside an- ti-HBV agents in 42 hospitals from 5 cities in Yangtze River valley during 2010－2011 were analyzed statistically by amount rank- ing method ，DDD ，DDDs sorting and ratio of the amount of drug dispensed to the number of prescription. RESULTS ：Among pa- tients who took nucleoside anti-HBV agents ，the majority in Shanghai were over 45 years old ，while the majority in other cities were between 18and 44years old ，with a male/female ratio of 2.81 1∶；there was great difference in the utilization of nucleoside an- ti-HBV agents ，and the regiment of adefovir entecavir accounted for over 70％of market share. CONCLUSIONS ：During 2010－ 2011，both the variety and the quantity of nucleoside anti-HBV a