ingebrigtsen 他汀类可以改善COPD的急性发作.pdf

Downloaded from / on December 29, 2014 - Published by Chronic obstructive pulmonary disease ORIGINAL ARTICLE Statin use and exacerbations in individuals with chronic obstructive pulmonary disease Truls S Ingebrigtsen,1,2,3 Jacob L Marott,2 Børge G Nordestgaard,2,3,4 Peter Lange,2,3,5,6 Jesper Hallas,7 Jørgen Vestbo8,9 ▸ Additional material is ABSTRACT published online only. To view Background We tested the hypothesis that statin use in Key messages these images and file please individuals with COPD is associated with a reduced risk of visit the journal online (http:// /10.1136/thoraxjnl- exacerbations. 2014-205795) Methods We identified 5794 individuals with COPD What is the key question? For numbered affiliations see and a measurement of C reactive protein (CRP) in the ▸ Do statins have beneficial effects on exacerbations end of article. Copenhagen General Population Study (2003–2008). in unselected individuals with COPD, and if so, During 3 years of follow-up we recorded exacerbations what might be part of the explanation? Correspondence to with hospital admissions or oral corticosteroid treatment. Professor Jørgen Vestbo, In a nested case-control design, matching on age, What is the bottom line? Department of Respiratory gender, smoking, COPD severity and comorbidity, we ▸ Several population based studies have indicated Medicine, Gentofte Hospital, Niels Andersens Vej, 65, estimated the