盐酸昂丹司琼足三里穴位注射预防肿瘤化疗所致.doc

盐酸昂丹司琼足三里穴位注射预防肿瘤化疗所致 恶心呕吐的临床研究 刘卓星1 刘文玲 黄国庆 朱浩图 杨海劲 程越 田丹 517000 河源 广东省河源市人民医院肿瘤中心 【摘要】 目的62例接受化疗的恶性肿瘤患者随机分为研究组和对照组。研究组32例昂丹司琼4mg通过单侧足三里穴位注射，对照组昂丹司琼8mg通过静脉注射，均在化疗前30分钟给药，观察患者恶心呕吐发生情况，必要时给予解救性止吐治疗（）。结果（CRR）vs．vs．组对化疗引起的急性呕吐（24小时内）完全缓解率（CRR）无显著性差异（8％vs.％，P=0），但对延迟性呕吐（24小时天）完全控制率（CCR）明显高于对照组（％vs.％，P=0037），化疗后未出现呕吐（天）的比例也明显高于对照组（分别为％vs％，P=0012）。化疗后人均呕吐发作次数也明显少于[(1.47±3.36）次／例vs．（±5.80）次／例，P=0029)。试验组呕吐控制时间明显长于对照组（P=0039）。±225.30）元/例vs．±296.40）元/例，P=0.031]。两组分别有％和的受试者出现轻度便秘、腹胀及头痛等（P=1），结论预防肿瘤化疗所致恶心呕吐优于，且安全。关键词: 盐酸昂丹司琼 足三里 穴位注射 化疗 恶心 呕吐 Randomized control clinical trail of the relative effect on ondansetron point-injection on Zusanli and intravenous injection to prevent chemotherapy-induced nausea and vomitting Liu zhuo-xing, Liu wen-ling, Huang guo-qing, Zhu hao-tu, Yang hai-jing, Cheng yue, Tian dan Department of Oncology, Heyuan peoples hospital,Heyuan 517000 ,China 【Abstract】: Objective：To ondansetron point-injection on Zusanli and intravenous injection to prevent chemotherapy-induced nausea and vomitting, so as to seeking ways to improve therapeutic level of prevent chemotherapy-induced nausea and vomitting. Methods：This study was performed as a randomized control clinical trial. The patients were randomized to receive a single dose of ondansetron g, point-injection on Zusanli（treatment group）, or ondansetron g by intravenous injection（ control group）, each administered 30 min before initiation of severely emetogenic chemotherapy. To observe the acute vomitting, delay vomitting, and acute nausea, and delay nausea, and administer rescue medication （intravenous injection ondansetron） if the patient needed. Results： patients were randomized to the clinical trail, and 32 pts receiving ondansetron point-injection on Zusanli, 30 pts receiving ondansetron intravenous injection. The proportion of patients with no nausea during the 24h after chemotherapy administration （acute period） in treatment group and control group were different （％vs．％，P=0．01 the