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DOI:10.1158/1078-0432.CCR-07-4481 Is There a Role for Circulating Tumor Cells in the Management of Breast Cancer? Daniel F. Hayes and Jeffrey Smerage Clin Cancer Res 2008;14:3646-3650. Published online June 16, 2008. Updated Version Access the most recent version of this article at: doi:10.1158/1078-0432.CCR-07-4481 Cited Articles This article cites 35 articles, 16 of which you can access for free at: /content/14/12/3646.full.html#ref-list-1 Citing Articles This article has been cited by 4 HighWire-hosted articles. Access the articles at: /content/14/12/3646.full.html#related-urls E-mail alerts Sign up to receive free email-alerts related to this article or journal. Reprints and To order reprints of this article or to subscribe to the journal, contact the AACR Subscriptions Publications Department at pubs@. Permissions To request permission to re-use all or part of this article, contact the AACR Publications Department at permissions@. Downloaded from on February 26, 2012 Copyright © 2008 American Association for Cancer Research DOI:10.1158/1078-0432.CCR-07-4481 CCR Practice of Translational Oncology Is There a Role for CirculatingTumor Cells in the Management of Breast Cancer? Daniel F. Hayes and Jeffrey Smerage Abstract Circulating tumor cells (CTC) can be identified and characterized in blood of patients with many solid tumors ,particularly breast cancer. Between 10% and 30% of patients with stage