2010生物信息学.pptVIP

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2010生物信息学ppt课件

* * * * * * * * 90 seconds * * * * * * * * * * * * * 90 seconds * 90 seconds * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * Venter基因组变异范围比Watson小 快/慢基因突变数目 YanHuang Venter Watson Black YanHuang 55.5 / 22 64 / 20.5 68.5 / 20.5 Venter 54 /16.5 68 / 21 Watson 69.5 / 16.5 Black 跟酵母比,人比线虫稍微近一点 From Copley et al. 1999, Current Opinion in Structural Biology, 9:408 Human-yeast closer, 12 Worm-yeast closer, 4 本人代表性生物信息学论文 Huang, S. (1994). Blimp-1 is the murine homolog of the human transcriptional repressor PRDI-BF1. Cell, 78: 9 Huang, S. (2008) Ancient fossil specimens are genetically more distant to an outgroup than extant sister species are. Rivista di Biologia / Biology Forum, 101: 93-108. Huang, S. (2008) The genetic equidistance result of molecular evolution is independent of mutation rates. J. Comp. Sci. Syst. Biol., 1: 92-102. Huang, S. (2009) Molecular evidence for the hadrosaur B. canadensis as an outgroup to a clade containing the dinosaur T. rex and birds. Rivista di Biologia / Biology Forum, 102: 20-22. Huang, S. (2009) Inverse relationship between genetic diversity and epigenetic complexity. Preprint available, Nature Precedings. Huang, S. (2010) The overlap feature of the genetic equidistance result, a fundamental biological phenomenon overlooked for nearly half of a century. Biological Theory, 5: 40-52. CAPS is more conserved in vertebrate Halabi, et al., 2009, Cell, 138: 774 Red sector Blue sector CAPS: Complexity Associated Protein Sectors 复杂相关域 (blue sector) Protein Sectors: Evolutionary Units of Three-Dimensional Structure Halabi, et al, Cell, 2009, 138: 774 The overlap feature is evidence of maximum genetic distance 0123456789 0123456789 0123xxxxxx A B A’ 012345x789 A 012345678x B 0123456789 0123456789 0123xxxxxx A B A’ 0123xxxxxx A 0123xxxxxx B 1/6 x 1/6 x 6 =

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