cal全程干预整理.pptVIP

* * * * * * Abstract OBJECTIVE: To evaluate three different therapeutic regimens for the prevention of?osteoporosis?in natural and surgical postmenopausal women who had been found to have rapid bone loss in analytical studies. METHODS: A total of 104 naturally or surgically postmenopausal women were studied, and subsequently followed-up during 1 year for avoidance of the influence of seasonal variation on bone mass, a factor overlooked in several studies. They were randomized into four groups of 26 patients each: the untreated control group (mean age 50 +/- 5 years); the hormonal replacement treatment (HRT) group (mean age 48 +/- 6 years), which was treated for 24 days each month with transdermal 17 beta-estradiol, 50 mg/day, together with medroxiprogesterone, 10 mg during 12 days; the calcium?group (mean age 50 +/- 4 years), which was treated with elemental?calcium, 1 g/day; and the calcitonin group (mean age 50 +/- 5 years), which was treated for 10 days each month with eel calcitonin, 40 IU/day and with elemental?calcium, 500 mg/day. Full-body bone densitometry, for measuring total body bone mineral content (TBBMC), was carried out in all the women at baseline and 1 year. TBBMC was corrected for body weight by dividing its value by body weight (TBBMC/W). RESULTS: After 1 year TBBMC/W was lower in every group: -2.14% (P 0.001) in the control group; -0.14% (P = NS) in the HRT group (P 0.05 vs. controls); -0.18% (P = NS) in the?calcium?group (P 0.05 vs. controls); and -0.06% (P = NS) in the calcitonin group (P 0.01 vs. controls; P 0.05 vs.?calcium?and HRT). CONCLUSIONS: These findings show that all three treatments are effective in the prevention of postmenopausal loss of bone mass. * * * * * * * 一项临床研究结果显示，骨质疏松性股骨粗隆间骨折术后(骨折后至手术时间为0-8天)即开始给予降钙素(200IU/天)和钙尔奇D?(1片/天，每片含钙600mg和维生素D125IU)治疗能缩短骨折愈合时间，促进骨折的愈合，同时也能减少骨钙的继续丢失，增加骨密度，提高骨的生物力学特性。研究说明在骨折早期即开始应用钙补充剂可促进骨折愈合 * 双磷酸盐类 阿仑磷酸盐 利塞磷酸盐 伊班磷酸盐 降钙素类 选择性雌激素类受体选择剂 结合性雌激素 Khosla, S. Melton, L. J., 3rd. Clinical pr