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SIRT6protectsagainstendothelialdysfunctionandatherosclerosisin.pptx

SIRT6protectsagainstendothelialdysfunctionandatherosclerosisin.pptx

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SIRT6protectsagainstendothelialdysfunctionandatherosclerosisin概要

IF:6.423;RESULT 1: Global deletion of SIRT6 impairs endotheliumdependent vasorelaxation;RESULT 2: Endothelium-specific deletion of SIRT6 impairs endothelium-dependent vasorelaxation;RESULT 3: SIRT6 haploinsufficiencyimpairs endotheliumdependent vasorelaxation in mice fed a high fat diet (HFD) ;RESULT 4: SIRT6 haploinsufficiency exacerbates the development of atherosclerosis in ApoE-/-mice;RESULT 4: SIRT6 haploinsufficiency exacerbates the development of atherosclerosis in ApoE-/-mice;RESULT 4: SIRT6 haploinsufficiency exacerbates the development of atherosclerosis in ApoE-/-mice;RESULT 5: SIRT6 haploinsufficiency increases the expression of adhesion molecule VCAM-1 in ApoE-/-mice;RESULT 6: SIRT6 inhibits monocyte adhesion to endothelial cells ;RESULT 6: SIRT6 inhibits monocyte adhesion to endothelial cells ;RESULT 7: SIRT6 overexpression alters endothelial transcriptional profile ;RESULT 7: SIRT6 overexpression alters endothelial transcriptional profile ;RESULT 7: SIRT6 overexpression alters endothelial transcriptional profile ;RESULT 7: SIRT6 overexpression alters endothelial transcriptional profile ;RESULT 8: SIRT6 decreases atherosusceptible gene TNFSF4 by deacetylating H3K9 at gene promoter ;Endothelial cells:

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