格列卫治疗慢粒白血病发生严重体液潴留1例报道及文献复习.pdfVIP

1720 ·论藩· 格则卫?台W慢收白.rIDJ商发生严盟体液滞留 1 例报道及文献复习. JL 佩艳，辞尚软，曾 t风，罗静，刘红，刘林，龚奕 (第三牢阪大学湖中排版院血液内料，重庆市隘*重点学科，重庆 400037) 摘 !lI!:阔的 探叶应用伊岛替尼(格别且〉地排慢性斡细胞白血病在生严重)滞留的炖理且具可能的成止机制，方法 报 现 1 倒在应用格列卫治拧憔性桩细胞白血病加速期患者的地程中，在生产量全身水肿、胸股股和族的处理过程Z且经验，蜡奇主献 对其在生的可能机制进行蝶边.结果 在用格列卫治咛慢艳的各阶段均有少批患者可能在生严重的水肿和体液满面的不良反 应，但在患宽朔和高姊患者枕多见.lI不足时处E盟有可能危;\\.生命，常高!t重视。将列且 ~I 越严重4肿的机制目前认舟崎典抑制 PÐGF 壶体的活性相吴.结论 在应用格列卫治拧慢粒时应警惕该是不良且应的是生.-旦出现需且时叶准处理并严密观事，曲 盛时停钩，待抱起执消失盾再开蜡用药是岳壶的。 关键词t 格列丑，惯性机相胞白血病;培拧s 体液满胃 文章蜻唔:1671 →834日 (2ο07)17-1720-02 中图分直是哥 :R733.72 ，日730.53 文献串串识码 :A Imatinib-induced 阻vere fluid retention in chronlc myelold leukemia; a c卧e report and literature revìe-w KοNGP白-yan.XUE S缸刷g叫削川 .ZENGDong-f，ni 1 01. CDepartment of Hematology .Xi叫iao HosPilal , Third Mili阳1Y Medical Uní时rsíty f Chollgqíng 400037 ,China) Abstract:Objectívè To study the treatment and its po罚sible mechanism of irnatini b-ìnduced severe fluid retention ín chromic mydoid leukemía(CML). Metbods The treatment prot:c附 lor 树vere anasarca , hydrothorax and !tcroperitoneum of a CML accd盯阳 ated pha .se patient getting imatinib therapy was represented. and the possible m时hanism was reviewed.且由ults A few CML pa tients treared with ímatínib oould g时 severe edema and fluid rctcntion in any ph刷刷 of the treatm削l.t， egpecially íor thf-吨ed paψ tlent罚。[ their illness were in accderatcd phuscs. The above symptoms needed emergency treatment !;hould be p~íd much attention to. The mechanism of imatini b-ïnduced 5evere edema was thought to be as~odated with inhib川ion of P DC-F retep阳r S ð(tivation. COI1c1usion The aoove síde effe.ts should be seríously cared during the CML t附lItment wÎth imatÎnib ， th股 tre.a tmcnts for the symp~ toms ánd the close observation should be applîe